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This vascular failure might be similar to that created with the endothelium-damaging agents major intoxication [24,25], myocardial infarction [23], and maintained severe intra-abdominal hypertension [22], or those created with major vessel(s) occlusion [14,15,16,20], veins [15,16,20] or arteries [14], peripheral [14,15,16] and central [20]

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Both act on lipid metabolism rather than central hunger circuits, making them relevant to research focused on adiposity endpoints independent of caloric intake